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The effect of two toothpaste detergents on the frequency
of recurrent aphthous mouth ulcers.
Herlofson BB, Barkvoll P.
Department of Oral Surgery and Oral Medicine, Dental Faculty, University of
Oslo, Norway.
The aim of the present clinical double-blind crossover study was to
investigate the effect of two different toothpaste detergents, sodium lauryl
sulfate (SLS) and cocoamidopropyl betaine (CAPB), as compared with a
detergent-free paste, on 30 patients with frequent occurrences of recurrent
aphthous ulcers. The study consisted of three 6-week periods during which
the patients brushed twice daily with the different test toothpastes. The
localization and number of new ulcers were assessed. A significantly
higher frequency of aphthous (mouth) ulcers was demonstrated when
the patients brushed with a Sodium Lauryl Sulfate - than with a CAPB-containing
or a detergent-free placebo paste. Sodium Lauryl Sulfate -free toothpaste
may thus be recommended for patients with recurrent aphthous (mouth) ulcers.
Publication Types: Clinical Trial Randomized. Controlled Trial
Sodium lauryl sulfate and recurrent
aphthous mouth ulcers. A preliminary study.
Herlofson BB, Barkvoll P.
Department of Oral Surgery and Oral Medicine, Dental Faculty, University
of Oslo, Norway.
Sodium lauryl sulfate (SLS), a synthetic detergent commonly used in
dentifrices, is an effective denaturant. The aim of the present
study was to investigate the effect of Sodium Lauryl Sulfate in patients
with recurrent aphthous mouth ulcers (RAU). Ten patients with multiple
minor RAU participated in the study. The mean incidence of RAU was 17.8
during a 3-month period before the study. The patients used a dentifrice
containing 1.2% Sodium Lauryl Sulfate for a test period of 3 months
followed by a dentifrice without SLS for the same time period. The results
showed a statistically significant decrease in the number of aphthous
mouth ulcers from 14.3 after using the SLS-containing dentifrice to 5.1
ulcers after brushing with the SLS-free dentifrice (p < 0.05). It is
suggested that the denaturing effect of Sodium Lauryl Sulfate on the oral
mucin layer, with exposure of the underlying epithelium, induces an
increased incidence of RAU.
Publication Types:
Clinical Trial
Randomized Controlled Trial
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